The role of thiol-disulfide and ischemia-modified albumin in the differential diagnosis of acute scrotum in children

Aim: Testicular torsion which is the most common cause of acute scrotum, a real surgical emergency. However, despite imaging techniques and laboratory studies used in differential diagnosis pathologies causing difficult. Therefore, there need for parameters that confirm testicular torsion.In our study, we aimed to investigate usability as parameter scrotum inflammation children via thiol-disulfide ischemia-modified albumin(IMA) levels. Methods: Of 60 children, 30 boys with healthy who were admitted circumcision included. The levels native thiol(-SH), total thiol (SH + SS), dynamic disulfide(SS), disulfide(SS)/total thiol(SH SS) % rate, albumin IMA measured. Patients’ pre-operative postoperative first day blood samples’ findings also compared. Results: Native thiol(p = 0.025), 0.032), disulfide(p 0.045), albumin(p <0.001) IMA(p group significantly higher than controls. epididymo-orchitis subgroup found subgroup. Pre post-operative similar (for all variables p>.05). Conclusion: evaluation thiol/disulfide homeostasis levels, detection changes favor oxidative stress might help but it cannot differentiate from an diagnosis.